Androgen Receptor
Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. Mutations in this gene are also associated with complete androgen insensitivity (CAIS).
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Androgen Receptor Related Products (480)
Related Products (480)
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Recombinant Proteins (1)
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Antibodies (2)
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2,3,4,5-Tetrachloro-4′-biphenylol
0 ImagesCat. No.: HY-184794CAS No.: 67651-34-72,3,4,5-Tetrachloro-4′-biphenylol is an Androgen receptor ligand with a pIC50 value of 4.79. 2,3,4,5-Tetrachloro-4′-biphenylol is an environmental chemical that exerts endocrine-disrupting activity.
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(E)-Octinoxate
0 ImagesSynonyms: (E)-Octyl methoxycinnamate(E)-Octinoxate is the isomer of Octinoxate (HY-B1234). Octinoxate is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage and can be used to reduce the appearance of scars. Octinoxate also has a complex androgenic and estrogenic effect.
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Androgen receptor-IN-3
0 ImagesCat. No.: HY-131953CAS No.: 926228-58-2Androgen receptor-IN-3 (Compound 22) is an androgen receptor inhibitor. Androgen receptor-IN-3 inhibits AR-driven transcriptional activity in LNCaP cells, with an IC50 of 5.04 μM.
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Nilutamide (Standard)
0 ImagesCat. No.: HY-13702RCAS No.: 63612-50-0Synonyms: Nilandron (Standard); RU 23908 (Standard)Nilutamide (Standard) is the analytical standard of Nilutamide. This product is intended for research and analytical applications. Nilutamide (Nilandron) is an orally active nonsteroidal androgen receptor antagonist with affinity for androgen receptors but not for progestogen, estrogen or glucocorticoid receptors. Nilutamide can be used to research prostate cancer. Nilutamide also has antischistosomal properties.
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Clascoterone (Standard)
0 ImagesCat. No.: HY-13331RCAS No.: 19608-29-8Synonyms: Cortexolone 17 alpha-propionate (Standard); Cortexolone 17α-propionate (Standard); CB-03-01 (Standard)Clascoterone (Standard) is the analytical standard of Clascoterone. This product is intended for research and analytical applications. Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist.
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(3R,3′R)-Astaxanthin
0 ImagesCat. No.: HY-N13475CAS No.: 60760-95-4(3R,3′R)-Astaxanthin is an androgen receptor binder. (3R,3′R)-Astaxanthin can be used in the research of prostate cancer.
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Trestolone (Standard)
0 ImagesCat. No.: HY-101734RCAS No.: 3764-87-2Synonyms: 7α-Methylnandrolone (Standard)Trestolone (Standard) (7α-Methylnandrolone (Standard)) is the analytical standard of Trestolone (HY-101734). This product is intended for research and analytical applications. Trestolone is a synthetic anabolic-androgenic steroid (AAS) of the nandrolone (19-nortestosterone) group.
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(3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol
0 ImagesCat. No.: HY-161701CAS No.: 1393651-00-7(3β,4β,17β)-17-(2-Pyridinylmethyl)androst-5-ene-3,4,17-triol is an androstane derivative with anticancer activity.
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N-Desmethyl enzalutamide (Standard)
0 ImagesSynonyms: N-Desmethyl MDV 3100 (Standard)N-desmethyl Enzalutamide (Standard) is the analytical standard of N-desmethyl Enzalutamide. This product is intended for research and analytical applications. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide.
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Anticancer agent 340
0 ImagesCat. No.: HY-184865CAS No.: 3032493-76-5Anticancer agent 340 is an orally active antitumor agent. Anticancer agent 340 can bind to both the androgen receptor (AR) and BRD4 protein simultaneously, dose-dependently inducing the formation of the AR-BRD4 ternary complex, inhibiting the expression of the downstream target gene HEXIM1 (Gene X), and activating the Caspase 3/7 pathway to initiate apoptosis. Its proliferation inhibition and apoptosis activities are both significantly AR expression-dependent. Anticancer agent 340 can be used to study AR/BRD4 driven malignancies such as castration-resistant prostate cancer (CRPC).
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Dimethomorph (Standard)
0 ImagesDimethomorph (Standard) is the analytical standard of Dimethomorph. This product is intended for research and analytical applications. Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 µM.
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(+)-JJ-74-138
0 ImagesCat. No.: HY-164371CAS No.: 2135545-34-3(+)-JJ-74-138, a novel non-competitive androgen receptor (AR) antagonist, is capable of inhibiting Enzalutamide-resistant CRPC.
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RU 58841 (Standard)
0 ImagesSynonyms: PSK-3841 (Standard); HMR-3841 (Standard)
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Zanoterone
0 ImagesCat. No.: HY-105122CAS No.: 107000-34-0Synonyms: WIN 49596Zanoterone is an orally active antagonist of the androgen receptor (AR) with a Ki of 2.2 μM. Zanoterone blocks the binding of androgens such as testosterone and dihydrotestosterone (DHT), inhibiting the androgen signaling pathway, thereby reducing androgen-dependent prostate hyperplasia and prostate cancer growth.
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5N-Bicalutamide
0 ImagesCat. No.: HY-125589CAS No.: 1845688-96-15N-Bicalutamide is an androgen receptor (AR) antagonist with a Ki of 0.15 nM. 5N-Bicalutamide is a derivative of Bicalutamide (HY-14249). 5N-Bicalutamide reacts with Cys784 in the AR binding pocket via an activated aryl nitrile group to form a reversible thioimidate covalent adduct, which significantly enhances its binding affinity and inhibitory potency. 5N-Bicalutamide is used in prostate cancer-related research.
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Fenarimol
0 ImagesSynonyms: EL 222Fenarimol (EL 222) is a potent and orally active fungicide. Fenarimol also is a androgen receptor inhibitor with an IC50 value of 19 µM. Fenarimol decreases the mRNA expression of PBP C3, ODC, IGF-1.
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Cl-4AS-1 (Standard)
0 ImagesCat. No.: HY-103245RCAS No.: 188589-66-4Cl-4AS-1 (Standard) is the analytical standard of Cl-4AS-1 (HY-103245). This product is intended for research and analytical applications. Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively).
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Prochloraz (Standard)
0 ImagesSynonyms: BTS 40542 (Standard)Prochloraz (Standard) is the analytical standard of Prochloraz. This product is intended for research and analytical applications. Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM.
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Inocoterone acetate
0 ImagesCat. No.: HY-106104CAS No.: 83646-86-0Synonyms: RU-38882; RU-882Inocoterone acetate (RU-38882) is a nonsteroidal antiandrogen. Inocoterone acetate binds to the androgen receptor and has antiandrogenic activity in animal models. Inocoterone acetate reduces inflammatory papules and pustules.
